R406 (free base) [841290-80-0]
HY-11108
CAS Number841290-80-0
Product group Chemicals
Estimated Purity99.07
Molecular Weight470.45
Overview
- SupplierMedChem Express
- Product NameR406 (free base) [841290-80-0]
- Delivery Days Customer10
- CAS Number841290-80-0
- CertificationResearch Use Only
- Estimated Purity99.07
- Molecular FormulaC22H23FN6O5
- Molecular Weight470.45
- Scientific DescriptionR406 free base is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a Ki of 30 nM, potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM, measured at an ATP concentration corresponding to its Km value. R406 free base reduces immune complex-mediated inflammation[1]. R406 free base also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM)[2].
- SMILESCOC1=CC(NC2=NC(NC3=NC(N4)=C(C=C3)OC(C)(C)C4=O)=C(C=N2)F)=CC(OC)=C1OC
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200
MSDS
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