R892
HY-103294
CAS Number229030-05-1
Product group Chemicals
Molecular Weight1154.36
Overview
- SupplierMedChem Express
- Product NameR892
- Delivery Days Customer9
- CAS Number229030-05-1
- CertificationResearch Use Only
- Molecular FormulaC58H83N13O12
- Molecular Weight1154.36
- Scientific DescriptionR892 is a selective and efficient bradyKinin B1 receptor antagonist with significant antagonistic activity. The pA2 values of R892 in human and rabbit B1 receptors are 8.8 and 8.6 respectively, indicating its strong anti-activity at these receptors. R892 exhibits selectivity with ID50 values of 2.8 nM and >600 nM for B1 and B2 receptors, respectively, and has no endogenous agonist activity. R892 is resistant to aminopeptidase and kininase II (ACE) degradation and exhibits metabolic stability[1].
- SMILESO=C([C@H]1N(CCC1)C([C@H](CCCNC(N)=N)NC([C@@H](NC(C)=O)CCCCN)=O)=O)N2[C@@H](CCC2)C(NCC(N(C)[C@H](C(N[C@@H](CO)C(N[C@@H](C(N[C@H](C(O)=O)[C@@H](C)CC)=O)CC3=CC4=CC=CC=C4C=C3)=O)=O)CC5=CC=CC=C5)=O)=O
- UNSPSC12352200