Rabbit Anti-Mouse lamda Light Chain antibody [RM110]

GeneTex

Rabbit Anti-Mouse lamda Light Chain antibody [RM110]

9

This antibody reacts to the lambda light chain of mouse immunoglobulins. No cross reactivity with the kappa light chain, human IgG, rat IgG, or goat IgG. The Fc region of RM110 has been engineered to eliminate Fc receptor binding.

Flow Cytometry, ImmunoPrecipitation, Western Blot, ELISA

Research Use Only

Monoclonal

RM110

Unconjugated

Igl

immunoglobulin lambda chain complex

Igl-x

Rabbit

IgG

Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two classes of light chains, kappa and lambda. This region represents the germline organization of the lambda light chain locus from the C57BL/6J inbred mouse strain. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. This locus has four J-C clusters and three V segments that constitute two transcriptional units. One of the J-C clusters is incapable of encoding a protein; the J and C gene segments in this cluster are considered pseudogenes. Inbred strains of laboratory mice lack an additional J-C cluster of pseudogenes and several additional V segments that are found in wild mice. [provided by RefSeq, Jul 2008]

Mouse

2°C to 8°C,-20°C or -80°C

12352203