Anti-GRB2 Purified

EXBIO

Anti-GRB2 Purified

7

Western blotting: Recommended dilution: 1-2 microg/ml, reducing conditions.

Western Blot

Research Use Only

PAb (554)

1 mg/ml

Grb2 (growth factor receptor-bound protein 2) is a highly conserved adaptor protein composed of central SH2 domain flanked by two terminal SH3 domains. Grb2 mediates coupling of receptor protein tyrosine kinases to a guanine nucleotide exchange factor Sos, thereby enabling the tyrosine kinases to stimulate activity of Ras and hence of MAP kinase pathway. Grb2 also can bind to receptor protein tyrosine phosphatases and affect their signaling.

Human

2°C to 8°C

12352203