(Rac)-ACT-451840 [1839508-99-4]

MedChem Express

(Rac)-ACT-451840 [1839508-99-4]

5

1839508-99-4

Research Use Only

C47H54N6O3

750.97

(Rac)-ACT-451840 is an isomer of ACT-451840 that exhibits significant antimalarial effects. (Rac)-ACT-451840 exhibits significant antimalarial activity against P. berghei-infected mice at a dose of 20 mg/kg (ED90=13 mg/kg), and has an inhibitory effect at a dose of 300 mg/kg. The ED90 of (Rac)-ACT-451840 in the P. falciparum humanized immunodeficient mouse model is 3.7 mg/kg. (Rac)-ACT-451840 is similar to artemisinin, with a rapid onset of action but requires repeated high doses.

CC(N(CC1)CCN1C(C=C2)=CC=C2CN(C(/C=C/C3=CC=C(C=C3)C(C)(C)C)=O)C(CC4=CC=CC=C4)C(N5CCN(CC5)CC6=CC=C(C=C6)C#N)=O)=O

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