(Rac)-BRD0705 [1597440-03-3]

MedChem Express

(Rac)-BRD0705 [1597440-03-3]

10

1597440-03-3

Research Use Only

99.17

C20H23N3O

321.42

(Rac)-BRD0705 is a less active racemate of BRD0705. BRD0705 is a potent, paralog selective and orally active GSK3alpha inhibitor with an IC50 of 66 nM and a Kd of 4.8 microM. BRD0705 displays increased selectivity for GSK3alpha (8-fold) versus GSK3beta (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML)[1][2].

O=C1C2=C(N=C3C(C2(CC)C4=CC=CC=C4)=CNN3)CC(C)(C)C1

-20°C,2°C to 8°C

12352200