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(Rac)-Lonafarnib [193275-86-4]

HY-15136B
MedChem Express
CAS Number193275-86-4
DownloadMSDS
Product group Chemicals
Molecular Weight638.82
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Overview

  • Supplier
    MedChem Express
  • Product Name
    (Rac)-Lonafarnib [193275-86-4]
  • Delivery Days Customer
    10
  • CAS Number
    193275-86-4
  • Certification
    Research Use Only
  • Molecular Formula
    C27H31Br2ClN4O2
  • Molecular Weight
    638.82
  • Scientific Description
    (Rac)-Lonafarnib (Sch66336 racemate) is the racemate of Lonafarnib. Lonafarnib is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras, K-ras and N-ras with IC50 values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities[1].
  • SMILES
    O=C(N1CCC(CC(N2CCC(C3C4=C(Br)C=C(Cl)C=C4CCC5=CC(Br)=CN=C53)CC2)=O)CC1)N
  • UNSPSC
    12131703