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ProductsBack/(Rac)-Upacicalcet [2649575-19-7]

(Rac)-Upacicalcet [2649575-19-7]

HY-109106B
MedChem Express
CAS Number2649575-19-7
Product group Chemicals
Estimated Purity95.0
Molecular Weight351.76
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Overview

  • Supplier
    MedChem Express
  • Product Name
    (Rac)-Upacicalcet [2649575-19-7]
  • Delivery Days Customer
    10
  • CAS Number
    2649575-19-7
  • Certification
    Research Use Only
  • Estimated Purity
    95.0
  • Molecular Formula
    C11H14ClN3O6S
  • Molecular Weight
    351.76
  • Scientific Description
    (Rac)-Upacicalcet is the racemate of Upacicalcet (HY-109106). Upacicalcet is a non-peptide calcimimetic that acts as a CaSR agonist (EC50 = 10.8 nM). Upacicalcet reduces serum intact parathyroid hormone (iPTH) and serum Ca2+ levels, reducing hypocalcemia and gastrointestinal complications. Upacicalcet improves vascular calcification and bone disorders in the Adenine (HY-B0152)-induced secondary hyperparathyroidism (SHPT) rat model. Upacicalcet inhibits cortical pore formation and reduces bone fibrosis in rats with chronic kidney disease (CKD). Upacicalcet is useful for studying SHPT[1][2].
  • SMILES
    O=C(NCC(N)C(O)=O)NC1=CC(S(=O)(O)=O)=CC(Cl)=C1C
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

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