(rac)-ZK-304709 [1010440-84-2]

MedChem Express

(rac)-ZK-304709 [1010440-84-2]

5

1010440-84-2

Research Use Only

C22H29ClN6O2

444.96

(rac)-ZK-304709 is an isoform of ZK-304709 and is an orally active multi-targeted tumor growth inhibitor that inhibits multiple cell cycle-dependent kinases (CDKs), vascular endothelial growth factor receptor kinases (VEGF-RTKs), and platelet-derived growth factor receptor kinase beta (PDGF-RTKbeta). (rac)-ZK-304709 can dose-dependently inhibit the proliferation and colony formation of neuroendocrine tumor (NET) cells. (rac)-ZK-304709 directly acts on NET cells by inducing G2 cell cycle arrest and apoptosis, while reducing the expression of MCL1, survivin, and HIF1alpha. (rac)-ZK-304709 effectively controls tumor growth by inducing apoptosis and inhibiting tumor-induced angiogenesis, and may become a potential agent for inhibiting NET[1].

O=C(C1=NNC=C1NC(C2=CC(N3CCN(C)CC3)=CC(Cl)=C2)=O)NC4CCCCC4

12352200