RAD1 Antibody

Cusabio

RAD1 Antibody

20

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

RAD1

RAD1 checkpoint DNA exonuclease

HRAD1, REC1, cell cycle checkpoint protein RAD1, DNA repair exonuclease REC1, DNA repair exonuclease rad1 homolog, RAD1 checkpoint clamp component, RAD1 homolog, cell cycle checkpoint protein Hrad1, checkpoint control protein HRAD1, exonuclease homolog RAD1, rad1-like DNA damage checkpoint protein

Rabbit

IgG

Cell cycle checkpoint protein RAD1

Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. Isoform 1 possesses 3->5 double stranded DNA exonuclease activity.

Human

-20°C or -80°C

41116161