Rad17 (phospho Ser645) antibody [EP1519Y]

GeneTex

Rad17 (phospho Ser645) antibody [EP1519Y]

9

Recommended Starting Dilutions:For WB: Use at a dilution of 1:2500 - 5000Optimal working dilution for a specific application should be determined by the investigator.

Western Blot

Research Use Only

Monoclonal

EP1519Y

Unconjugated

RAD17

RAD17 checkpoint clamp loader component

CCYC, HRAD17, R24L, RAD17SP, RAD24, cell cycle checkpoint protein RAD17, RAD1 homolog, RAD17 homolog, RF-C activator 1 homolog, Rad17-like protein, cell cycle checkpoint protein (RAD17)

Rabbit

IgG

Cell cycle checkpoint protein RAD17

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013]

Human

-20°C or -80°C,2°C to 8°C

41116161