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IHC-P analysis of breast adenocarcinoma tissue using GTX83736 RAD9A antibody [7B11]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50
IHC-P analysis of breast adenocarcinoma tissue using GTX83736 RAD9A antibody [7B11]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50
IHC-P analysis of breast adenocarcinoma tissue using GTX83736 RAD9A antibody [7B11]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50

RAD9A antibody [7B11] - Overexpression Validated

Research Use Only
GTX83736
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetRAD9A
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Overview

  • Supplier
    GeneTex
  • Product Name
    RAD9A antibody [7B11] - Overexpression Validated
  • Delivery Days Customer
    9
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    7B11
  • Concentration
    2 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID5883
  • Target name
    RAD9A
  • Target description
    RAD9 checkpoint clamp component A
  • Target synonyms
    cell cycle checkpoint control protein RAD9A; DNA repair exonuclease rad9 homolog A; hRAD9; RAD9; RAD9 homolog A
  • Host
    Mouse
  • Isotype
    IgG2a
  • Scientific Description
    Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds - endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths - and DNA ligase I (LIG1) on long-patch base excision repair substrates. RAD9A possesses 3->5 double stranded DNA exonuclease activity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex.
  • Reactivity
    Human
  • Storage Instruction
    2°C to 8°C,-20°C or -80°C
  • UNSPSC
    12352203