Raloxifene 4-glucuronide

MedChem Express

Raloxifene 4-glucuronide [182507-22-8]

10

182507-22-8

Research Use Only

C34H35NO10S

649.71

Raloxifene 4-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4-glucuronide binds to estrogen receptor with an IC 50 of 370 microM. [1] [2] . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFbeta3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression [3] .

O[C@H]([C@H]([C@@H]([C@@H](C(O)=O)O1)O)O)[C@@H]1OC2=CC=C(C3=C(C(C4=CC=C(OCCN5CCCCC5)C=C4)=O)C6=CC=C(O)C=C6S3)C=C2

12352200