RanGAP1 blocking peptide

GeneTex

RanGAP1 blocking peptide

9

Research Use Only

RANGAP1

Ran GTPase activating protein 1

Fug1, RANGAP, SD, ran GTPase-activating protein 1, segregation distorter homolog

RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle. [provided by RefSeq, Jul 2008]

-20°C or -80°C,2°C to 8°C

41116100

Human