RANK/TNFRSF11A, Human (HEK293, His)

MedChem Express

RANK/TNFRSF11A, Human (HEK293, His)

10

Research Use Only

98.0

TNFRSF11A

TNF receptor superfamily member 11a

CD265; familial expansile osteolysis; FEO; LOH18CR1; loss of heterozygosity, 18, chromosomal region 1; ODFR; OFE; OPTB7; osteoclast differentiation factor receptor; OSTS; Paget disease of bone 2; PDB2; RANK; receptor activator of NF-KB; receptor activator of nuclear factor-kappa B; TRANCE receptor; TRANCER; TRANCE-R; tumor necrosis factor receptor superfamily member 11A; tumor necrosis factor receptor superfamily, member 11a, NFKB activator

Tumor necrosis factor receptor superfamily member 11A

RANK (TNFRSF11A) is a receptor activator of nuclear factor kappaB (NF-kappaB), which is involved in bone metabolism and immune system function. RANK is mainly expressed by osteoblasts/stromal cells, and is associated with the formation of giant cell tumor of bone (GCTBs) [1]. RANK combined with RANKL ligand activated the RANKL/RANK/ OPG system to regulate bone resorption [2]. RANKL/RANK is also a regulator of dendritic cell (DC)-T cell interaction, which is associated with mammary epithelial formation and central nervous system thermoregulation in lactating female [3][4]. RANK/TNFRSF11A Protein, Human (HEK293, His) has 183 amino acids (I30-P212), produced by HEK293 cells with C-terminal 6*His-tag.

-20°C

41116100