RANK/TNFRSF11A, Human (HEK293, His)

MedChem Express

RANK/TNFRSF11A, Human (HEK293, His)

10

Research Use Only

98.0

TNFRSF11A

TNF receptor superfamily member 11a

CD265, FEO, LOH18CR1, ODFR, OFE, OPTB7, OSTS, PDB2, RANK, TRANCE-R, TRANCER, tumor necrosis factor receptor superfamily member 11A, Paget disease of bone 2, TRANCE receptor, familial expansile osteolysis, loss of heterozygosity, 18, chromosomal region 1, osteoclast differentiation factor receptor, receptor activator of NF-KB, receptor activator of nuclear factor-kappa B, tumor necrosis factor receptor superfamily, member 11a, NFKB activator

Tumor necrosis factor receptor superfamily member 11A

RANK (TNFRSF11A) is a receptor activator of nuclear factor kappaB (NF-kappaB), which is involved in bone metabolism and immune system function. RANK is mainly expressed by osteoblasts/stromal cells, and is associated with the formation of giant cell tumor of bone (GCTBs) [1]. RANK combined with RANKL ligand activated the RANKL/RANK/ OPG system to regulate bone resorption [2]. RANKL/RANK is also a regulator of dendritic cell (DC)-T cell interaction, which is associated with mammary epithelial formation and central nervous system thermoregulation in lactating female [3][4]. RANK/TNFRSF11A Protein, Human (HEK293, His) has 183 amino acids (I30-P212), produced by HEK293 cells with C-terminal 6*His-tag.

-20°C

41116100