Raphin1 (acetate) [2242616-04-0]

MedChem Express

Raphin1 (acetate) [2242616-04-0]

10

2242616-04-0

Research Use Only

99.93

h301

C10H12Cl2N4O2

291.13

Raphin1 acetate is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 acetate binds strongly to the R15B-PP1c holophosphatase (Kd=33 nM), and shows ~30-fold selective in binding R15B-PP1c over R15A-PP1c. Raphin1 acetate crosses the blood-brain barrier, and reduces organismal and molecular deficits in a mouse model of a protein misfolding disease[1].

N=C(N/N=C/C1=CC=CC(Cl)=C1Cl)N.CC(O)=O

2°C to 8°C

12352200