RASGRP2 antibody
GTX108616
ApplicationsImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetRASGRP2
Overview
- SupplierGeneTex
- Product NameRASGRP2 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID10235
- Target nameRASGRP2
- Target descriptionRAS guanyl releasing protein 2
- Target synonymsCALDAG-GEFI, CDC25L, RAS guanyl-releasing protein 2, F25B3.3 kinase-like protein, RAS guanyl nucleotide-releasing protein 2, RAS guanyl releasing protein 2 (calcium and DAG-regulated), calcium and DAG-regulated guanine nucleotide exchange factor I, calcium and diacylglycerol-regulated guanine nucleotide exchange factor I, cdc25-like protein, guanine exchange factor MCG7
- HostRabbit
- IsotypeIgG
- Protein IDQ7LDG7
- Protein NameRAS guanyl-releasing protein 2
- Scientific DescriptionThe protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Three alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Miyazaki S, Takino JI, Nagamine K, et al. RasGRP2 Attenuates Oxygen Deprivation-Induced Autophagy in Vascular Endothelial Cells. Biol Pharm Bull. 2023,46(11):1512-1516. doi: 10.1248/bpb.b23-00317Read this paper
- Liu Y, Ouyang Y, Feng Z, et al. RASGRP2 is a potential immune-related biomarker and regulates mitochondrial-dependent apoptosis in lung adenocarcinoma. Front Immunol. 2023,14:1100231. doi: 10.3389/fimmu.2023.1100231Read this paper
- Montenont E, Bhatlekar S, Jacob S, et al. CRISPR-edited megakaryocytes for rapid screening of platelet gene functions. Blood Adv. 2021,5(9):2362-2374. doi: 10.1182/bloodadvances.2020004112Read this paper
- Takino JI, Sato T, Nagamine K, et al. The inhibition of Bax activation-induced apoptosis by RasGRP2 via R-Ras-PI3K-Akt signaling pathway in the endothelial cells. Sci Rep. 2019,9(1):16717. doi: 10.1038/s41598-019-53419-4Read this paper
- Niemz J, Kliche S, Pils MC, et al. The Guanine-Nucleotide Exchange Factor Caldag Gefi Fine-Tunes Functional Properties of Regulatory T Cells. Eur J Microbiol Immunol (Bp). 2017,7(2):112-126. doi: 10.1556/1886.2017.00007Read this paper
- Takino J, Nagamine K, Hori T. Ras guanyl nucleotide releasing protein 2 affects cell viability and cell-matrix adhesion in ECV304 endothelial cells. Cell Adh Migr. 2013,7(3):262-6. doi: 10.4161/cam.24082Read this paper



