Rat Acetyl CoA carboxylase Ready-To-Use IHC Kit

Bioss

Rat Acetyl CoA carboxylase Ready-To-Use IHC Kit

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ImmunoHistoChemistry

Research Use Only

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiplealternatively spliced transcript variants divergent in the 5 sequence and encoding distinct isoforms have been found for this gene.

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