Anti-Ms CD8a Alexa Fluor(r) 488

EXBIO

Anti-Ms CD8a Alexa Fluor(r) 488

7

Flow cytometry: Recommended dilution: 2 microg/ml.

Flow Cytometry, ImmunoCytoChemistry

Research Use Only

53-6.7

0.5 mg/ml

AlexaFluor 488

IgG2a

The CD8a (CD8 alpha) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.

Mouse

2°C to 8°C

12352203