WB analysis of GTX00343-pro Rat VEGFA protein (active).
Rat VEGFA protein (active)
GTX00343-PRO
ApplicationsFunctional Assay
Product group Proteins / Signaling Molecules
Protein IDP16612
Overview
- SupplierGeneTex
- Product NameRat VEGFA protein (active)
- Delivery Days Customer9
- ApplicationsFunctional Assay
- CertificationResearch Use Only
- ConjugateUnconjugated
- Protein IDP16612
- Protein NameVascular endothelial growth factor A
- Scientific DescriptionThis gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2015]
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352202
References
- COX2 Enhances Neovascularization of Inflammatory Tenocytes Through the HIF-1alpha/VEGFA/PDGFB Pathway. Deng B et al., 2021, Front Cell Dev BiolRead more