RbAp48 antibody [11G10]
GTX70232
ApplicationsFunctional Assay, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Neutralisation/Blocking
Product group Antibodies
ReactivityHuman, Mouse
TargetRBBP4
Overview
- SupplierGeneTex
- Product NameRbAp48 antibody [11G10] - Orthogonal Validated
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsFunctional Assay, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Neutralisation/Blocking
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID11G10
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID5928
- Target nameRBBP4
- Target descriptionRB binding protein 4, chromatin remodeling factor
- Target synonymsCAF-1 subunit C; CAF-I 48 kDa subunit; CAF-I p48; chromatin assembly factor 1 subunit C; chromatin assembly factor I p48 subunit; chromatin assembly factor/CAF-1 p48 subunit; histone-binding protein RBBP4; lin-53; MSI1 protein homolog; nucleosome-remodeling factor subunit RBAP48; NURF55; RBAP48; RBBP-4; retinoblastoma-binding protein 4; retinoblastoma-binding protein p48
- HostMouse
- IsotypeIgG2b
- Protein IDQ09028
- Protein NameHistone-binding protein RBBP4
- Scientific DescriptionThis gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Loss of Immunohistochemical Reactivity in Association With Handling-Induced Dark Neurons in Mouse Brains. Soontornniyomkij V et al., 2020 Apr, Toxicol PatholRead more
- RbAp48 Protein Is a Critical Component of GPR158/OCN Signaling and Ameliorates Age-Related Memory Loss. Kosmidis S et al., 2018 Oct 23, Cell RepRead more
- Proteomic analysis of honokiol-induced cytotoxicity in thyroid cancer cells. Chou HC et al., 2018 Aug 15, Life SciRead more
- YC-1 inhibits proliferation of breast cancer cells by down-regulating EZH2 expression via activation of c-Cbl and ERK. Chang LC et al., 2014 Sep, Br J PharmacolRead more
- Molecular mechanism for age-related memory loss: the histone-binding protein RbAp48. Pavlopoulos E et al., 2013 Aug 28, Sci Transl MedRead more
- Mitochondrial genome instability resulting from SUV3 haploinsufficiency leads to tumorigenesis and shortened lifespan. Chen PL et al., 2013 Feb 28, OncogeneRead more
- ATF-2 regulates lipopolysaccharide-induced transcription in macrophage cells. Hirose N et al., 2009 Jul 17, Biochem Biophys Res CommunRead more
- Interaction of histone acetylases and deacetylases in vivo. Yamagoe S et al., 2003 Feb, Mol Cell BiolRead more
- Histone H3 lysine 4 methylation disrupts binding of nucleosome remodeling and deacetylase (NuRD) repressor complex. Zegerman P et al., 2002 Apr 5, J Biol ChemRead more
- The histone deacetylase HDAC3 targets RbAp48 to the retinoblastoma protein. Nicolas E et al., 2001 Aug 1, Nucleic Acids ResRead more