RbAp48 antibody [13D10]
GTX70234
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetRBBP4
Overview
- SupplierGeneTex
- Product NameRbAp48 antibody [13D10]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IP: 1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID13D10
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID5928
- Target nameRBBP4
- Target descriptionRB binding protein 4, chromatin remodeling factor
- Target synonymsNURF55, RBAP48, lin-53, histone-binding protein RBBP4, CAF-1 subunit C, CAF-I 48 kDa subunit, CAF-I p48, MSI1 protein homolog, RBBP-4, chromatin assembly factor 1 subunit C, chromatin assembly factor I p48 subunit, chromatin assembly factor/CAF-1 p48 subunit, nucleosome-remodeling factor subunit RBAP48, retinoblastoma-binding protein 4, retinoblastoma-binding protein p48
- HostMouse
- IsotypeIgG2b
- Protein IDQ09028
- Protein NameHistone-binding protein RBBP4
- Scientific DescriptionThis gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
- ReactivityHuman
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Kim MJ, Cervantes C, Jung YS, et al. PAF remodels the DREAM complex to bypass cell quiescence and promote lung tumorigenesis. Mol Cell. 2021,81(8):1698-1714.e6. doi: 10.1016/j.molcel.2021.02.001Read this paper
- Sun JM, Chen HY, Davie JR. Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin. J Biol Chem. 2007,282(45):33227-36.Read this paper
- Schultz DC, Friedman JR, Rauscher FJ 3rd. Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD. Genes Dev. 2001,15(4):428-43.Read this paper
- Skowyra D, Zeremski M, Neznanov N, et al. Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex. J Biol Chem. 2001,276(12):8734-9.Read this paper
- Humphrey GW, Wang Y, Russanova VR, et al. Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1. J Biol Chem. 2001,276(9):6817-24.Read this paper

