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RbAp48 antibody [13D10]

GTX70234
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
Product group Antibodies
TargetRBBP4
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Overview

  • Supplier
    GeneTex
  • Product Name
    RbAp48 antibody [13D10] - Orthogonal Validated
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IP: 1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    13D10
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID5928
  • Target name
    RBBP4
  • Target description
    RB binding protein 4, chromatin remodeling factor
  • Target synonyms
    CAF-1 subunit C; CAF-I 48 kDa subunit; CAF-I p48; chromatin assembly factor 1 subunit C; chromatin assembly factor I p48 subunit; chromatin assembly factor/CAF-1 p48 subunit; histone-binding protein RBBP4; lin-53; MSI1 protein homolog; nucleosome-remodeling factor subunit RBAP48; NURF55; RBAP48; RBBP-4; retinoblastoma-binding protein 4; retinoblastoma-binding protein p48
  • Host
    Mouse
  • Isotype
    IgG2b
  • Protein IDQ09028
  • Protein Name
    Histone-binding protein RBBP4
  • Scientific Description
    This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • PAF remodels the DREAM complex to bypass cell quiescence and promote lung tumorigenesis. Kim MJ et al., 2021 Apr 15, Mol Cell
    Read more
  • Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin. Sun JM et al., 2007 Nov 9, J Biol Chem
    Read more
  • Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD. Schultz DC et al., 2001 Feb 15, Genes Dev
    Read more
  • Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex. Skowyra D et al., 2001 Mar 23, J Biol Chem
    Read more
  • Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1. Humphrey GW et al., 2001 Mar 2, J Biol Chem
    Read more

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