Rebamipide

AbMole BioScience

Rebamipide

9

90098-04-7

Chemical

C19H15ClN2O4

370.79

Rebamipide (OPC12759) is a cholecystokinin-1 (CCK1) receptor inhibitor that inhibits [125I]BH-CCK-8S with an IC50 of 37.7 uM. Rebamipide is an orally effective gastroprotective agent. Rebamipide enhances the production of endogenous PGs (particularly intragastric PGE2) by inducing COX-2 expression, thereby protecting the gastric mucosa from injury. Rebamipide also has anti-proliferative activity against gastric cancer cells.

OC(=O)C(CC1=CC(=O)NC2=C1C=CC=C2)NC(=O)C3=CC=C(Cl)C=C3

12352200