Rebastinib [1020172-07-9]

MedChem Express

Rebastinib [1020172-07-9]

4

1020172-07-9

Research Use Only

99.91

C30H28FN7O3

553.59

Rebastinib (DCC-2036) is an orally active, non-ATP-competitive Bcr-Abl inhibitor for Abl1WT and Abl1T315I with IC50s of 0.8 nM and 4 nM, respectively. Rebastinib also inhibits SRC, KDR, FLT3, and Tie-2, and has low activity to seen towards c-Kit.

CC(C)(C)C1=NN(C(NC(NC2=C(F)C=C(OC3=CC(C(NC)=O)=NC=C3)C=C2)=O)=C1)C4=CC=C5C(C=CC=N5)=C4

-20°C, 3 years; 4°C, 2 years (Powder)

12352200