Rebeccamycin

BioViotica

Rebeccamycin [93908-02-2]

10

93908-02-2

Research Use Only

>98%

Danger,Excepted quantity

C27H21Cl2N3O7

570.4

Antibiotic. Structurally similar to staurosporine. Selective activity against several cancer cell lines. DNA intercalator, resulting in catalytic inhibition of topoisomerases I. Shows significant antitumor properties in vitro (IC50 = 480 nM against mouse B16 melanoma cells and IC50 = 500 nM against P388 leukemia cells). Does not show any inhibitory activity against protein kinases. - Chemical. CAS: 93908-02-2. Formula: C27H21Cl2N3O7. MW: 570.4. Isolated from Streptomyces sp. Antibiotic. Weak topoisomerase I (Topo I) inhibitor. Structurally similar to staurosporine. Does not show any inhibitory activity against protein kinases. Shows significant antitumor properties in vitro (IC50 = 480 nM against mouse B16 melanoma cells and IC50 = 500 nM against P388 leukemia cells).

COC1C(O)C(O)C(OC1CO)N1C2=C3NC4=C(C=CC=C4Cl)C3=C3C(=O)NC(=O)C3=C2C2=C1C(Cl)=CC=C2

-20°C,2°C to 8°C

UN 3462

12352200