Rebeccamycin

Bioss

Rebeccamycin

16

Research Use Only

Unconjugated

>98%

C27H21Cl2N3O7

570.4

Antibiotic. Structurally similar to staurosporine. Selective activity against several cancer cell lines. DNA intercalator, resulting in catalytic inhibition of topoisomerases I. Shows significant antitumor properties in vitro (IC50 = 480 nM against mouse B16 melanoma cells and IC50 = 500 nM against P388 leukemia cells). Does not show any inhibitory activity against protein kinases.

COC1C(O)C(O)C(OC1CO)N1C2=C3NC4=C(C=CC=C4Cl)C3=C3C(=O)NC(=O)C3=C2C2=C1C(Cl)=CC=C2

-20°C

12161600