Recombinant Human BMP-3 beta (GDF10)
Z100095
Product group Proteins / Signaling Molecules
Overview
- SupplierApplied Biological Materials
- Product NameRecombinant Human BMP-3 beta (GDF10)
- Delivery Days Customer9
- CertificationResearch Use Only
- Scientific DescriptionBMPs are proteins that act to induce the differentiation of mesenchymal-type cells into chondrocytes and osteoblasts before initiating bone formation. They promote the differentiation of cartilage-forming cells and bone-forming cells near sites of fractures but also at ectopic locations. Some of the proteins induce the synthesis of alkaline phosphatase and collagen in osteoblasts. Some BMPs act directly on osteoblasts and promote their maturation while at the same time suppressing myogenous differentiation. Other BMPs promote the conversion of typical fibroblasts into chondrocytes and are capable also of inducing the expression of an osteoblast phenotype in non-osteogenic cell types. Intracellular signaling following engagement of receptors for some BMP proteins has been shown to involve the action of SMAD proteins. BMP3 is a glycoprotein that is identical with osteogenin. Human and rat mature proteins are 98% identical.
- UNSPSC12352202