Recombinant Human FGF4

Biorbyt

Recombinant Human FGF4

10

Application Notes: For research use only. Minimum Sample Size: 50microg/vial

Research Use Only

≥95%

Fibroblast growth factor 4

Fibroblast Growth Factor 4 (FGF4) is one of a family of 18 secreted canonical FGF proteins that interact with 4 signaling tyrosine kinase FGF receptors. FGF4 is most highly expressed in the embryonic ectoderm, axial, paraxial, and lateral plate mesoderm, and tailbud. The FGF4 subfamily (FGF4, 5, 6) bind to receptors expressed predominantly in mesenchymal tissues (FGFR1c, 2c, 3c, 4), and play important roles in the early stages of embryonic development and organogenesis. FGF signaling is required for proper embryonic axial growth and segmentation. In a mouse model, creation of a gain of function FGF4 copy to replace an inactive FGF 8 gene was able to rescue limb development; however, it also caused abnormal tissue deposition and postaxial polydactyly, highlighting that levels of FGF proteins throughout embryonic development must be properly controlled for normal limb formation. The signal transduction mediated by the FGF/FGFR4 axis is extremely complex, which includes PKC, ERK1/2, AKT, Src, and GSK3beta signaling cascades. The homodimer of FGFR4 forms when binding to either canonical FGF subfamily members or FGF19 subfamily members. Heparin or heparin sulfate is required for the binding of canonical FGF subfamily members to FGFR4, whereas KLB acts as a co-receptor of FGFR4 to facilitate FGFR4 interacting with FGF19 subfamily members. When FGFR4 forms protein complexes with FGFs, it can be phosphorylated on three main tyrosine residues: Y642, Y643, and Y764.

CHO Cell - Human

-20°C or -80°C,2°C to 8°C

12352202