Recombinant Human FLT-3L

Biorbyt

Recombinant Human FLT-3L

10

Application Notes: For research use only. Minimum Sample Size: 50microg/vial

Research Use Only

≥95%

Fms-related tyrosine kinase 3 ligand

Fms-like tyrosine kinase-3 ligand (Flt-3L) is an important regulator of hematopoiesis. The first 26 amino acids comprise the signal peptide which is absent from the mature protein. It has an extracellular domain, a transmembrane domain, and a cytoplasmic tail. Flt-3L is expressed by various hematopoietic progenitor cells (HPC). Its receptor, Flt3, is expressed on myeloid, lymphoid, and dendritic cell progenitors and is considered an important growth and differentiation factor for several hematopoietic lineages. Flt-3L causes the activation of signal transduction networks mainly through phospatidylinositol-3-kinase (PI3K) and the cascade of RAS, supporting the activation of AKT (protein kinase B, PKB), signal transducer and activator transcription factor (STAT) and extracellular-signal regulated kinase 1 and 2 (ERK1/2). Activating mutations of Flt3 are frequently found in acute myeloid leukemia (AML) patients and are associated with a poor clinical prognosis.

CHO Cell - Human

-20°C or -80°C,2°C to 8°C

12352202