Loaded Herceptin on ProA Biosensor, can bind Recombinant Human Her2 / ERBB2 Protein, no Tag (Cat. No. 10004-HCCH) with an affinity constant of 1.8 nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested).
Loaded Herceptin on ProA Biosensor, can bind Recombinant Human Her2 / ERBB2 Protein, no Tag (Cat. No. 10004-HCCH) with an affinity constant of 1.8 nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested).
Recombinant Human Her2/ERBB2 Protein (ECD), HPLC-verified
10004-HCCH
Product group Molecular Biology
Overview
- SupplierSino Biological
- Product NameRecombinant Human Her2/ERBB2 Protein (ECD), HPLC-verified
- Delivery Days Customer10
- Category SupplierHer2/ERBB2 Proteins
- CertificationResearch Use Only
- Scientific DescriptionHuman epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.
- UNSPSC12352204
References
- Krawczyk N, et al. (2009) HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor. Anticancer Res. 29(10): 4019-24.Read more
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