Recombinant Human IL-2

Biorbyt

Recombinant Human IL-2

10

Application Notes: For research use only. Minimum Sample Size: 100microg/vial

Research Use Only

≥95%

Interleukin-2

Interleukin-2 (IL-2), a 15.5-kDa variably glycosylated globular protein, was first described as T cell growth factor. IL-2 is mainly produced by CD4+ T lymphocytes (naive, memory, and T helper [Th] 1) following antigenic stimulation, by type 2 and 3 innate lymphoid cells in the small intestine, and to a lesser extent by activated CD8+ T cells, B cells, and by other innate immune entities such as natural killer (NK) and NKT lymphocytes, dendritic cells (DCs), monocytes, or mast cells. Once secreted, IL-2 is consumed in an autocrine/paracrine manner by neighboring cells that harbor its receptor, IL-2R. The latter consists of a hetero-complex of up to three subunits: alpha, beta, and gamma, also known as CD25, CD122, and CD132, respectively. The gamma subunit is ubiquitously expressed on most hematopoietic cells. It is also referred to as the common chain (labeled gammac), as it is shared with the receptors for IL-4, -7, -9, -15, and -21. Binding of IL-2 to IL-2R activates JAK1/3. In turn, these kinases activate the PI3Ks/PIP3/AKT/mTOR/p70S6K and Ras/Raf/MAP2K1/2/ERK1/2 signaling cascades and phosphorylate STAT5 to modulate the activity and de novo expression of multiple downstream regulators involved in protein synthesis, autophagy, cell metabolism, survival, proliferation, and differentiation. IL-2 is a pleiotropic cytokine with immunostimulatory or immunoinhibitory activity depending on the target cell. Its effects on nonhematopoietic and innate immune cells remain poorly deciphered. Above all, IL-2 stands out as a well-established regulator of T cell development and homeostasis.

CHO Cell - Human

-20°C or -80°C,2°C to 8°C

12352202