Recombinant Human Interleukin-2 (rHuIL-2)

Biorbyt

Recombinant Human Interleukin-2 (rHuIL-2)

10

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20°C. Further dilutions should be made in appropriate buffered solutions.

Research Use Only

>97%

Interleukin 2 is a protein that has a variety of immunologic functions, the most notable being the ability of IL-2 to promote the proliferation and maturation of activated T cells. A comparison of the amino acid sequences of human and murine IL-2 shows an approximately 60% sequence similarity, and human sequence IL-2 has been found to be active on murine cell lines. Some of the biological activities attributed to IL-2 include: . induction of secretion of interferon-gamma and tumor necrosis factors -alpha and -beta from peripheral blood mononuclear cells . stimulation of the rate of synthesis of c-myc RNA and transferrin receptor . activation of neutrophils . stimulation of proliferation and maturation of activated helper T cells . stimulation of proliferation of activated and natural killer cells and tumor-infiltrating lymphocytes, as well as enhancement of the ability of these cytotoxic lymphocytes to kill target cells . induction of the expression of IL-2 receptors on T cells . stimulation of proliferation of antibody-producing B cells

E.coli

-20°C,-20°C or -80°C,2°C to 8°C

12352202