Recombinant human NT-proBNP protein, N-His

Bioss

Recombinant human NT-proBNP protein, N-His

16

ELISA

Research Use Only

Unconjugated

>95%

NPPB

natriuretic peptide B

BNP, Iso-ANP, natriuretic peptides B, brain natriuretic factor prohormone, brain type natriuretic peptide, gamma-brain natriuretic peptide, natriuretic peptide precursor B, natriuretic protein, preproBNP, proBNP

Natriuretic peptides B

Brain natriuretic peptide (BNP), also known as B-type natriuretic peptide, is a hormone secreted by cardiomyocytes in the heart ventricles in response to stretching caused by increased ventricular blood volume. The 32-amino acid polypeptide BNP is secreted attached to a 76mino acid N-terminal fragment in the prohormone called NT-proBNP (BNPT), which is biologically inactive. Once released, BNP binds to and activates the atrial natriuretic factor receptor NPRA, and to a lesser extent NPRB, in a fashion similar to atrial natriuretic peptide (ANP) but with 10-fold lower affinity. The biological half-life of BNP, however, is twice as long as that of ANP, and that of NT-proBNP is even longer, making these peptides better targets than ANP for diagnostic blood testing.

-80°C

41116124

Human, Other Species