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PR-369 | WASP-121GST, Wiskott-Aldrich Syndrome Protein, human, recombinant, E. coli, Recognized GTPases: Cdc42, TC10,TCL.

WASP-121GST, Wiskott-Aldrich Syndrome Pr... | PR-369 | Jena Bioscience

WASP-121GST, Wiskott-Aldrich Syndrome Protein, human, recombinant, E. coli, Recognized GTPases: Cdc42, TC10,TCL

The Wiskott-Aldrich syndrome protein (WASP) is the founding member of a family of proteins that have emerged as crucial effectors of Rho GTPases and activators of the cytosceletalorganizing complex Arp2/3. WASP has been shown to be intimately involved in many pathways that influence the function of the immune system. WASP-121 comprises the amino acids 201-321 of the native WASP sequence. This domain is essential for the binding of Cdc42 to WASP. The GST-Tag facilitates the proteins application in typical GST pull down assays.

PR-398 | AF6-RBDGST (residues 1-141), GTP-H-Ras binding cytoplasmic protein, Afadin - Ras-binding domain, human, recombinant, E. coli.

AF6-RBDGST (residues 1-141), GTP-H-Ras b... | PR-398 | Jena Bioscience

AF6-RBDGST (residues 1-141), GTP-H-Ras binding cytoplasmic protein, Afadin - Ras-binding domain, human, recombinant, E. coli

The amino terminus of Af6 was identified as the Rasbinding site. Additionally to the Ras-binding Af6 also binds Rap. ZO-1, a protein involved in the formation of tight junctions, also binds to Af6 close to the amino terminus thereby competing with Ras binding. These data suggest a participation of Af6 in the regulation of cell-cell contacts via a Ras-modulated interaction with ZO-1. In contrast to the well characterized effectors Raf, RalGEF, and PI(3)kinase, Af6 is a protein with no enzymatic function. It seems to serve as a scaffolding component for protein complexes. This would represent a new type of Ras effector because Ras binding in this case does not lead to the activation of the enzymatic activity of the effector.

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