Recombinant SARS-CoV-2 Papain-Like Protease, N-His

Bioss

Recombinant SARS-CoV-2 Papain-Like Protease, N-His

16

ELISA

Research Use Only

Unconjugated

>90%

ORF1ab

ORF1a polyprotein;ORF1ab polyprotein

GU280_gp01, ORF1a polyprotein;ORF1ab polyprotein, 2'-O-ribose methyltransferase, 3'-to-5' exonuclease, 3C-like proteinase, RNA-dependent RNA polymerase, endoRNAse, helicase, leader protein, nsp10, nsp11, nsp2, nsp3, nsp4, nsp6, nsp7, nsp8, nsp9

Replicase polyprotein 1ab

Replication of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) requires proteolytic processing of the replicase polyprotein by two viral cysteine proteases, a chymotrypsin-like protease (3CLpro) and a papain-like protease (PLpro). These proteases are important targets for development of antiviral drugs that would inhibit viral replication and reduce mortality associated with outbreaks of SARS-CoV. PLpro is a cysteine protease located within the non-structural protein 3 (NS3) section of the viral polypeptide. PLPro activity is required to process the viral polyprotein into functional, mature subunits; specifically, PLPro cleaves a site at the amino-terminus of the viral replicase region. In addition to its role in viral protein maturation, PLPro possesses a deubiquitinating and deISGylating activity. In vivo, this protease antagonizes innate immunity by inhibiting IRF3-induced production of type I interferons.

-80°C

41115809

Virus, Other Species