(rel)-Lopinavir-d8 [1322625-54-6]
HY-14588S
Overview
- SupplierMedChem Express
- Product Name(rel)-Lopinavir-d8 [1322625-54-6]
- Delivery Days Customer14
- CAS Number1322625-54-6
- CertificationResearch Use Only
- Molecular FormulaC37H40D8N4O5
- Molecular Weight636.85
- Scientific Description(rel)-Lopinavir-d8 ((rel)-ABT-378-d8) is the deuterium labeled Lopinavir (HY-14588)[1]. Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with Kis of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity[2][3]. Lopinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 14.2 microM[4].
- SMILESO=C1NCCCN1C([2H])(C(N[C@H](C[C@@H]([C@@H](NC(COC2=C(C=CC=C2C)C)=O)CC3=CC=CC=C3)O)CC4=CC=CC=C4)=O)C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H]
- Storage Instruction2°C to 8°C
- UNSPSC12131703