(rel)-MK 287 [143445-03-8]

MedChem Express

(rel)-MK 287 [143445-03-8]

9

143445-03-8

Research Use Only

C25H34O9S

510.60

(rel)-MK 287 ((rel)-L-680573) is a relative configuration of MK 287. MK 287, a tetrahydrofuran analog, potently inhibited [3H]C18-PAF binding to human platelet, polymorphonuclear leukocyte (PMN) and lung membranes with Kis of 6.1 nM, 3.2 nM and 5.49 nM, respectively. MK 287 inhibits PAF-induced lethality in mice and PAF-induced bronchoconstriction in guinea pigs[1].

O=S(CCO)(C1=CC([C@H]2O[C@@H](CC2)C3=CC(OC)=C(C(OC)=C3)OC)=CC(OC)=C1OCCC)=O

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