rel-PROTAC PARP1 degrader

MedChem Express

rel-PROTAC PARP1 degrader

14

Research Use Only

98.99

C58H63Cl2N11O10

1145.09

rel-PROTAC PARP1 degrader is the relative configuration of ROTAC PARP1 degrader (HY-114324). ROTAC PARP1 degrader is a PARP1 degrader based on MDM2 E3 ligand. It induces significant PARP1 cleavage and programmed cell death. PROTAC PARP1 degrader at 10 microM at 24 h inhibits MDA-MB-231 cell line with an IC50 of 6.12 microM.

O=C(CN(C(N1C(C2=CC=C(OC)C=C2OC(C)C)=N[C@H](C3=CC=C(Cl)C=C3)[C@@H]1C4=CC=C(Cl)C=C4)=O)CC5)N5CC(NCCOCCOCCOCCOCCN6N=NC(C7=CC=C(N8N=C(C(C(N)=O)=CC=C9)C9=C8)C=C7)=C6)=O

-20°C,2°C to 8°C

12352200