rel-Zotatifin [2098191-54-7]

MedChem Express

rel-Zotatifin [2098191-54-7]

10

2098191-54-7

Research Use Only

97.32

C28H29N3O5

487.56

rel-Zotatifin is the racemic isomer of Zotatifin, acts as an eIF4A inhibitor with activity less than Zotatifin. Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5-UTRs (IC50=2 nM) and interferes with the assembly of the eIF4F initiation complex[1].

N#CC1=CC=C([C@@]2(O3)[C@@](C4=C3C=C(OC)N=C4OC)(O)[C@H](O)[C@H](CN(C)C)[C@H]2C5=CC=CC=C5)C=C1

-20°C,2°C to 8°C

12352200