RepSox---TGF-beta Type I Receptor ALK5 Inhibitor

Bioss

RepSox---TGF-beta Type I Receptor ALK5 Inhibitor

16

Research Use Only

98.0

RepSox (E-616452 or SJN 2511) is a highly potent, selective inhibitor of the TGF-beta type I receptor ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation, respectively. It has good selectivity for ALK5 over a range of kinases, including p38 MAPK, JNK1 and GSK3 (IC50 > 16 microM). RepSox is able to successfully replace Sox2 in reprogramming by inhibiting transforming growth factor-beta (Tgf-beta) signaling, which in turn induces Nanog expression. Effect of RepSox inducing reprogramming does not require chromatin remodeling. RepSox is found to be efficient at generating iPSCs.

-20°C

51202000