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Resmetirom (MGL-3196)

M3184
AbMole BioScience
CAS Number920509-32-6
DownloadDatasheet
Product group Chemicals
Estimated Purity0.9987
Molecular Weight435.22
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Overview

  • Supplier
    AbMole BioScience
  • Product Name
    Resmetirom (MGL-3196)
  • Delivery Days Customer
    9
  • CAS Number
    920509-32-6
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Estimated Purity
    0.9987
  • Molecular Formula
    C17H12Cl2N6O4
  • Molecular Weight
    435.22
  • Scientific Description
    Resmetirom (MGL-3196, VIA-3196, resmetirom) is a potentially first-in-class, liver-targeted, orally active, selective thyroid hormone receptor (THR)-bèta agonist with an EC50 value of 0.21 uM. Resmetirom avoids the activation of THR-alfa receptors that mediate thyroid hormone activity outside of the liver, including the heart and bone. Resmetirom avoids the activation of THR-alfa receptors that mediate extrahepatic (including cardiac and skeletal) thyroid hormone activity and can be used in studies of non-alcoholic steatohepatitis (NASH).
  • SMILES
    CC(C)C1=CC(=NNC1=O)OC2=C(Cl)C=C(C=C2Cl)N3N=C(C#N)C(=O)NC3=O
  • UNSPSC
    12352200