REST Antibody, Biotin conjugated

Cusabio

REST Antibody, Biotin conjugated

20

ELISA

Research Use Only

Polyclonal

Biotin

REST

RE1 silencing transcription factor

DFNA27; GINGF5; HGF5; neural-restrictive silencer factor; neuron restrictive silencer factor; NRSF; RE1-silencing transcription factor; repressor binding to the X2 box; WT6; XBR

Rabbit

IgG

RE1-silencing transcription factor

Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression.

Human

-20°C or -80°C

12352203