Resveratrol-3-O-sulfate sodium [858127-11-4]

TargetMol Chemicals

Resveratrol-3-O-sulfate sodium [858127-11-4]

44

858127-11-4

Research Use Only

Resveratrol-3-O-sulfate sodium

C14H11NaO6S

330.29

Resveratrol-3-O-sulfate is a metabolite of resveratrol . In U-937 cells stimulated with LPS, resveratrol-3-O-sulfate (1 microM) decreases the expression of IL-1alpha, IL-1beta, and IL-6 by 61.2, 76.6, and 42.2%, respectively, and decreases the release of TNF-alpha and IL-6 to similar levels as resveratrol. It has antioxidant activity in a Trolox assay, dose-dependently decreases growth of Caco-2 colorectal adenocarcinoma cells when used at concentrations ranging from 10 to 100 microM, and induces apoptosis at concentrations of 25 and 50 microM. Resveratrol-3-O-sulfate also displaces rosiglitazone from the outer mitochondrial protein mitoNEET (IC50 = 3.36 microM for the human protein), indicating that it binds to the thiazolidine-2,4-dione (TZD) binding pocket.

3 years

[Na].Oc1ccc(\C=C\c2cc(O)cc(OS(O)(=O)=O)c2)cc1

-20°C

12352200