Chemical Structure
Chemical Structure
Resveratrol [501-36-0]
AG-CN2-0033
Overview
- SupplierAdipoGen Life Sciences
- Product NameResveratrol
- Delivery Days Customer10
- CAS Number501-36-0
- CertificationResearch Use Only
- Estimated Purity>98%
- Hazard InformationWarning
- Molecular FormulaC14H12O3
- Molecular Weight228.2
- Scientific DescriptionChemical. CAS: 501-36-0. Formula: C14H12O3. MW: 228.2. Isolated from Polygonum cuspidatum. Potent phenolic antioxidant found in grapes and red wine. Eicosanoid synthesis and platelet aggregation inhibitor. Estrogen receptor agonist. Chemopreventive. Specific inhibitor of cyclooxygenase-1 (COX-1). Anti-inflammatory. Ribonucleotide reductase and DNA synthesis. Arrests cell cycle at S/G2 phase. Anticancer and antiproliferative compound. Apoptosis inducer. Protein kinase D inhibitor. Does not inhibit PKC. Autophagy inducer. Potent SIRT1 (sirtuin 1) activator. Neuroprotective. Adipogenesis inhibitor. PGC-1alpha activator. Sonic hedgehog (Shh) signaling pathway modulator. Gli1 mRNA expression inhibitor. Downregulates Gli transcriptional activity. Cardioprotective. Anti-diabetic. Senescence modulator. Extends lifespan. Inhibitor of NLRP3 inflammasome activation. - Potent phenolic antioxidant found in grapes and red wine [1, 19]. Eicosanoid synthesis and platelet aggregation inhibitor [2]. Estrogen receptor agonist [3]. Chemopreventive [4, 15]. Specific inhibitor of cyclooxygenase-1 (COX-1) [4]. Anti-inflammatory [4, 21]. Ribonucleotide reductase and DNA synthesis [5]. Arrests cell cycle at S/G2 phase [6, 23]. Anticancer and antiproliferative compound [7, 16]. Apoptosis inducer [8, 23]. Protein kinase D inhibitor. Does not inhibit PKC [9]. Autophagy inducer [10, 23]. Potent SIRT1 (sirtuin 1) activator [11, 22]. Neuroprotective [12, 18]. Adipogenesis inhibitor [13]. PGC-1alpha activator [14]. Sonic hedgehog (Shh) signaling pathway modulator. Gli1 mRNA expression inhibitor. Downregulates Gli transcriptional activity [17]. Cardioprotective [19, 21]. Anti-diabetic [20]. Senescence modulator. Extends lifespan [22]. Inhibitor of NLRP3 inflammasome activation [24].
- SMILESOC1=CC=C(\C=C\C2=CC(O)=CC(O)=C2)C=C1
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200
References
- Antioxidant activity of resveratrol in red wine: N.J. Miller & C. Rice-Evans; Clin. Chem. 41, 1789 (1995)
- The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease: C.R. Pace-Asciak, et al.; Clin. Chem. Acta 235, 207 (1995)
- Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor: B.D. Gehm, et al.; PNAS 94, 14138 (1997)
- Cancer chemopreventive activity of resveratrol, a natural product derived from grapes: M. Jang, et al.; Science 275, 218 (1997)
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase: M. Fontecave, et al.; FEBS Lett. 421, 277 (1998)
- Resveratrol arrests the cell division cycle at S/G2 phase transition: F.D. Ragione, et al.; BBRC 250, 53 (1998)
- Antiproliferative effect of synthetic resveratrol on human breast epithelial cells: O.P. Mgbonyebi, et al.; Int. J. Oncol. 12, 865 (1998)
- Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells: J. Dörrie, et al.; Cancer Res. 61, 4731 (2001)
- Inhibition of protein kinase D by resveratrol: R.S. Haworth & M. Avkiran; Biochem. Pharmacol. 62, 1647 (2001)
- Resveratrol-induced autophagocytosis in ovarian cancer cells: A.W. Jr. Opipari, et al.; Cancer Res. 64, 696 (2004)