Retinol Binding Protein

Athens Research

Retinol Binding Protein

9

In Vitro Diagnostics, Diabetes, Inflammation, Cardiovascular Disease, Biotherapeutics

Research Use Only

≥95% by SDS-PAGE.

Retinol-binding protein 4

Retinol binding protein 4 (RBP4) is a member of the lipocalin family and serves as the primary transporter of retinol (vitamin A) in the bloodstream, present at about 40 mg/L in healthy individuals. Synthesized mainly in the liver, RBP4 binds retinol and forms a complex with transthyretin, which prevents its loss via kidney filtration and ensures efficient delivery of vitamin A to peripheral tissues. Beyond its canonical role in retinoid homeostasis, RBP4 functions as an adipokine and has been implicated in metabolic regulation. Elevated RBP4 levels are strongly associated with insulin resistance, obesity, type 2 diabetes, gestational diabetes, metabolic syndrome, and cardiovascular diseases, correlating with increased levels of APO B-containing lipoproteins such as LDL and VLDL. RBP4 can also trigger adipose tissue inflammation, linking it to chronic metabolic and inflammatory conditions. Clinically, RBP4 is under investigation as a biomarker for metabolic disorders and chronic kidney disease, and as a potential therapeutic target in diabetes and cardiovascular risk management.

more then 1 year

Source human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.

≤ -20°C

12352202