More than 130 suppliers

In-house tech support

Call +31 (0)26 326 44 50

Bio-Connect

Products
Products
Antibodies
Chemicals
Proteins / Signaling Molecules
Assays
DNA / RNA / Vectors
Cell Culture
Genome Editing and Engineering
Molecular Biology
Lysates / Extracts
Expression
Labware / Accesories
Body Products
Technique Specific Products
Arrays / Slides
Diagnostic
Biologicals
Microbiology
Promotions
All product groups
Support your research
For 15 years, we connect life science researchers specialized in the import and distribution of life science reagents from global suppliers.
How can we help?
Suppliers
Suppliers
Life Sciences
Diagnostics
Services
Become a partner
All Suppliers
Support your research
For 15 years, we connect life science researchers specialized in the import and distribution of life science reagents from global suppliers.
How can we help?
Industries
Industries
Biotech, Pharma & CRO
Academia
Diagnostics
Environment
Food
Veterinary
All industries
Support your research
For 15 years, we connect life science researchers specialized in the import and distribution of life science reagents from global suppliers.
How can we help?
News

Website
Events
Promotions
About us
About us
Our company
Our team
For suppliers
Vacatures
Events
Promotions
Support your research
For 15 years, we connect life science researchers specialized in the import and distribution of life science reagents from global suppliers.
How can we help?
Contact
Contact
Headquarters
Customer Service
Technical support
Accountmanagers
FAQ
Support your research
For 15 years, we connect life science researchers specialized in the import and distribution of life science reagents from global suppliers.
How can we help?

ProductsBack/Revumenib [2169919-21-3]

Revumenib Chemical Structure. CAS No. : 2169919-21-3

Revumenib Chemical Structure. CAS No. : 2169919-21-3

Revumenib Chemical Structure. CAS No. : 2169919-21-3

Revumenib [2169919-21-3]

HY-136175

CAS Number2169919-21-3

Product group Chemicals

Estimated Purity99.88

Molecular Weight630.82

Overview

Supplier
MedChem Express
Product Name
Revumenib [2169919-21-3]
Delivery Days Customer
9
CAS Number
2169919-21-3
Certification
Research Use Only
Estimated Purity
99.88
Molecular Formula
C32H47FN6O4S
Molecular Weight
630.82
Scientific Description
Revumenib (SNDX-5613) is a potent and specific Menin-MLL inhibitor with a binding Ki of 0.149 nM and a cell based IC50 of 10-20 nM. Revumenib can be used for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML)[1].
SMILES
O=C(N(CC)C(C)C)C1=CC(F)=CC=C1OC2=CN=CN=C2N3CC4(CCN(C[C@H]5CC[C@H](NS(=O)(CC)=O)CC5)CC4)C3
Storage Instruction
-20°C,2°C to 8°C
UNSPSC
12352200

References

Yan F, Li J, Milosevic J, et al. KAT6A and ENL Form an Epigenetic Transcriptional Control Module to Drive Critical Leukemogenic Gene-Expression Programs. Cancer Discov. 2022,12(3):792-811. doi: 10.1158/2159-8290.CD-20-1459
Read this paper
Nguyen N, Gudmundsson KO, Soltis AR, et al. Recruitment of MLL1 complex is essential for SETBP1 to induce myeloid transformation. iScience. 2022,25(1):103679. doi: 10.1016/j.isci.2021.103679
Read this paper
Barajas JM, Rasouli M, Umeda M, et al. Acute myeloid leukemias with UBTF tandem duplications are sensitive to menin inhibitors. Blood. 2024,143(7):619-630. doi: 10.1182/blood.2023021359
Read this paper
Mill CP, Fiskus W, Das K, et al. Causal linkage of presence of mutant NPM1 to efficacy of novel therapeutic agents against AML cells with mutant NPM1. Leukemia. 2023,37(6):1336-1348. doi: 10.1038/s41375-023-01882-4
Read this paper

MSDS

FAQ

Go to our frequently asked questions