The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA012032(RFFL Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200)
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA012032(RFFL Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200)
RFFL Antibody
CSB-PA012032
ApplicationsELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetRFFL
Overview
- SupplierCusabio
- Product NameRFFL Antibody
- Delivery Days Customer20
- ApplicationsELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID117584
- Target nameRFFL
- Target descriptionring finger and FYVE like domain containing E3 ubiquitin protein ligase
- Target synonymsCARP2; CARP-2; caspase 8 and 10 associated RING protein-2; caspase regulator CARP2; caspases-8 and -10-associated RING finger protein 2; E3 ubiquitin-protein ligase rififylin; FRING; FYVE-RING finger protein SAKURA; RIFIFYLIN; ring finger and FYVE-like domain containing 1; RING finger and FYVE-like domain-containing protein 1; RING finger protein 189; RING-type E3 ubiquitin transferase rififylin; RNF189; RNF34L
- HostRabbit
- IsotypeIgG
- Protein IDQ8WZ73
- Protein NameE3 ubiquitin-protein ligase rififylin
- Scientific DescriptionE3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates Lys-48-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Also ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate apoptosis downstream of death domain receptors. Also negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation.
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C
- UNSPSC41116161
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