RFWD3 antibody [C1C3]

GeneTex

RFWD3 antibody [C1C3]

9

WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot

Research Use Only

Polyclonal

0.96 mg/ml

Unconjugated

Liquid

RFWD3

ring finger and WD repeat domain 3

E3 ubiquitin-protein ligase RFWD3; FANCW; RING finger and WD repeat domain-containing protein 3; RING finger protein 201; RING-type E3 ubiquitin transferase RFWD3; RNF201

Rabbit

IgG

E3 ubiquitin-protein ligase RFWD3

E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53.

Human

-20°C or -80°C,2°C to 8°C

12352203