RG-12525

MedChem Express

RG-12525 [120128-20-3]

10

120128-20-3

Research Use Only

98.31

C25H21N5O2

423.47

RG-12525 is a a specific, competitive and orally effective antagonist of the peptidoleukotrienes , LTC4 , LTD4 and LTE4 , inhibiting LTC4-, LTD4- and LTE4-inducd guinea pig parenchymal strips contractions, with IC 50 s of 2.6 nM, 2.5 nM and 7 nM, respectively; RG-12525 is also a peroxisome proliferator-activated receptor gamma ( PPAR-gamma ) agonist with IC 50 of appr 60 nM and a potent inhibitor of CYP3A4 , with a K i value of 0.5 microM.

C1(COC2=CC=C(OCC3=CC=CC=C3CC4=NN=NN4)C=C2)=NC5=CC=CC=C5C=C1

-20°C,2°C to 8°C

12352200