Rg3039 [1005504-62-0]

TargetMol Chemicals

Rg3039 [1005504-62-0]

4

1005504-62-0

Chemical

Research Use Only

Rg3039

99.58%

C21H23Cl2N5O

432.35

Rg3039 (PF-06687859) is a potent DcpS inhibitor. DcpS is a therapeutic target for spinal muscular atrophy. Spinal muscular atrophy (SMA) is caused by deletion or mutation of both copies of the SMN1 gene which produces an essential protein known as SMN. RG3039 improves motor function in SMA mice. RG3039 also showed activity to improve survival, function and motor unit pathologies in two SMA mouse models.

3 years

Nc1nc(N)c2c(OCC3CCN(Cc4c(Cl)cccc4Cl)CC3)cccc2n1

-20°C

12352200